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[6] El glutatin se sintetiza en dos pasos dependientes del trifosfato de adenosina: En primer lugar, la gamma-glutamilcistena se sintetiza a partir del L-glutamato y la cistena a travs de la enzima gamma-glutamilcistena sintetasa (tambin conocida como ligasa glutamato-cistena (GCL) ligasa)

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Neuron 22 , 147156 (1999)

Unlike direct GPX4 inhibition, which remains difficult to deploy in vivo owing to bioavailability and systemic toxicity concerns, targeting enzymes that sustain the reduced CoQ 10 (CoQ 10 H 2 , ubiquinol) pool may provide a more tractable and context-selective strategy to lower the ferroptotic threshold in tumors

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They dissolve in water and do not build up in the tissues, so the body can remove excess vitamins in the urine