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Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis

(168) documented a positive correlation between increased levels of serum ferritin and the incidence of glaucoma

[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered

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This demonstrates the critical role of the CHAC2-NRF2 signaling pathway in protecting against oxidative stress and highlights CHAC2 as a potential therapeutic target for mitigating APAP-induced liver damage (Zhai et al., 2022)