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The up-regulation of EGF coupled with loss of cell cycle control (both p16 INK4A and p14 ARF ) was shown to induce higher-grade glioma formation in vivo

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doi: 10.1136/gutjnl-2019-318664 61 MassierLChakarounRKovacsPHeikerJT
Bioinformatics 25 , i161-168