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JCI Insight 2023;8:e164921.ArticlePubMedPMC 28

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In KEEPS, women with normal transporter activity had lower circulating levels of estrone and 17estradiol sulfate than those with lower activity, while those with reduced transporter activity demonstrated a greater decrease in night sweats among women on active treatment.55 Additional research using larger cohorts of women is needed in order to utilized a pharmacogenomic approach to maximize hormone treatments