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Proper Administration Technique To maximize absorption and effectiveness: Clear nasal passages : Gently blow your nose before administration Prime the pump : If first use, pump several times until a fine mist appears Position correctly : Tilt head slightly forward (not back) Spray and breathe : Administer spray while gently inhaling through the nose Avoid blowing : Wait 5-10 minutes before blowing your nose Alternate nostrils : Rotate between nostrils with each dose Timing Considerations Strategic timing can enhance results: Morning : Supports daytime recovery and cellular repair processes Pre-workout : May enhance workout-induced adaptation signals Evening : Aligns with natural overnight recovery and growth hormone release Post-injury : Immediate and consistent dosing following acute injury Consistency matters more than perfectionestablishing a regular routine supports optimal results

D+Q treatment mitigated pathogenic ventricle enlargement, aberrant cerebral blood flow and white matter hyperintensity pathology (Figure 2ac, adapted from (21))