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Some chemicals cause an acute injury and others produce chronic renal changes that may lead to end-stage renal failure and renal malignancies

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[DOI] [PMC free article] [PubMed] [Google Scholar] 236.Maciejewski ML, Smith VA, Berkowitz TSZ, Arterburn DE, Mitchell JE, Olsen MK, Liu CF, Livingston EH, Funk LM, Adeyemo A, Bradley KA

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Most of the error in such an approach arises from inaccurate differential solvation free energies of the acid and conjugate base which is removed in our approach using a correction based on the realization that the gas-phase acidities have only a small systematic error relative to the dominant systematic error in the differential solvation