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Significant ROS induction has been reported during HBV infection, whereby the viral protein HBx plays a key role in the induction of oxidative stress 51

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This 3-h incubation period also increased intracellular calcium transient frequency supporting a role for increased neurotransmission

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In a dose proportionality study involving multiple CMI doses, steady-state plasma concentrations (C ss) and area-under-plasma-concentration-time curves (AUC) of CMI and CMI's major active metabolite, desmethylclomipramine (DMI), were not proportional to dose over the ranges evaluated, i.e., between 25 to 100 mg/day and between 25 to 150 mg/day, although C ssand AUC are approximately linearly related to dose between 100 to 150 mg/day