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If load exceeds capacity, injury persists

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As shown in Figure 5B5F, characteristic morphological changes were observed in lung sections after LPS administration, including notable immune cell infiltration, interstitial edema, alveolar wall thickness, and hemorrhage

Despite this relatively short half-life in circulation, the downstream metabolic effects persist for significantly longer due to the sustained activation of lipolytic enzymes and metabolic pathways initiated by the peptide