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Under normal physiological condition, only a handful of hepatocytes are in proliferation state, but exhibit strong regenerative ability once stimulated, either through tissue damage or tissue injury

Activation of deiodinase leads to a high rate of conversion of FT4 to FT3, resulting in low FT4 levels and high FT3 levels

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doi:10.1016/0531-5565(83)90031-1

b) supplementation at least for 12 weeks