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Diagnosis integrates clinical symptoms, B12 levels (or active B12/MMA/homocysteine where appropriate), antibody results, and exclusion of other causes

doi: 10.1093/jxb/erz234 55 IakimovaE

The potential use of receptor-mediated endocytosis for oral drug delivery

The anti-apoptotic properties of melatonin can be associated with increasing expression of apoptosis inhibitor proteins from the Bcl-2 and HSP70 family in nervous tissue, as well as inhibiting the activity of key apoptosis enzymes from the caspase family (Koh, 2008

b , c , KaplanMeier plots showing the overall survival of KRAS mutant CRC patients ( b ) and KRAS WT CRC patients ( c ) from the TCGA database

Repletion of cysteine stores should reestablish conversion of -glutamyl phosphate to -glutamyl cysteine, thereby preventing conversion of -glutamyl phosphate to 5-oxoproline and breaking the futile ATP-depleting cycle