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It also needs a well functioning exocrine pancreas to produce the required enzymes, and your stomach to produce intrinsic factor to be able to digest vitamin B12 properly
In older people, the first symptoms of pernicious anemia are often confusion, slowness, irritability, and apathy

But does any supplement really help

Prevalence of Polymorphisms in the Human UDP-Glucuronosyltransferase 2B Family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y) Cancer Epidemiol Biomarkers Prev
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Am J Physiol Cell Physiol