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Many studies found that vegans who didnt supplement with B12 generally had high homocysteine levels

Growth, body composition, and cardiovascular and nutritional risk of 5- to 10-y-old children consuming vegetarian, vegan, or omnivore diets

Bacteria are exquisitely sensitive to environmental cues and can initiate new genetic programs within minutes of detecting changes in resource availability (i.e., iron, phosphate, nitrogen, carbohydrates, or oxygen,), signals from other stressed or damaged bacteria (i.e., acyl-homoserine lactones or autoinducing peptides), or host signals of damage or inflammation (i.e., temperature, products of host cell damage, cytokines, or neurotransmitters) [59,60,61,62,63,64,65,66]

The early program proved it directly

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it is also known as non-insulin-dependent or adult-onset diabetes