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two published tirzepatide case series (Naranjo "probable"), FAERS reporting odds ratio 22.55 for allodynia across GLP-1 with tirzepatides neuro-AE proportion lower than semaglutides, class cohort signal (aHR 2.15) in related agents
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This happens because certain MTHFR mutations (C667T and A129C) lower the amount of active folate being produced in the body, and the use of vitamin B12 requires the active form of folate
