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Given the important roles of IGF-IR in tumor progression, inhibition of IGF-IR activity has been proposed as a therapeutic strategy for solid tumors and hematologic malignancies [20]

In the hepatocyte cytosol, where the NAD + concentration is high, lactate is oxidized to pyruvate by the liver isoenzyme of lactate dehydrogenase (EC 1.1.1.27)
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Zinc acts as a nutraceutical substance to maintain the barrier function of the epithelium (141)

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[DOI] [PubMed] [Google Scholar] 56.McClements B.M., Bingham A., Callender M.E., Trimble E.R