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Cysteine desulfuration is accomplished by alternate reactions catalyzed by cystathionine -synthase (CBS), cystathionine -lyase (CTH), and 3-mercaptopyruvate sulfurtransferase (MPST) (Fig

It is considered as a region distinguished in space and function, which is comprised by different cell populations, namely, cancer cells, epithelial cells, extracellular matrix, stromal fibroblasts, immune cells (lymphocytes, macrophages, and mast cells), and vascular cells (endothelial, pericytes, and smooth muscle cells) (43, 44)