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Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissue

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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

414 FDA-approved drugs and clinical trials targeting CSCs The clinical translation of CSC-targeted therapies has been challenging because of tumor heterogeneity, cellular plasticity, and the ability of CSCs to evade immune surveillance

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It was also verified that one kind of long noncoding RNA, LINC00662, could activate the Wnt/-catenin pathway in an autocrine manner by increasing Wnt3a expression and secretion, and also in a paracrine manner to promote M2 macrophage polarization, leading to HCC tumorigenesis and metastasis in vivo 27 ( Figure 2 )