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These results demonstrate that serum T4 levels can be artificially elevated among physiologically stressed individuals, and thus serum T4 and TSH levels are poor markers for tissue thyroid levels in this patient population (see Figure 2)

Dietary modification is an important prevention strategy, as poor diet accounts for approximately 45% of cardiometabolic deaths in the United States and an estimated 10 million CVD deaths annually worldwide (3, 4)

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( a ) Propionylcarnitine abundance in cells treated with the IDH1 inhibitor (IDH1i) supplemented with KG (n = 8 technical replicates representative from 3 independent experiments in each cell line pair)

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