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226-228 A trial in which 36 subjects with fibromyalgia received placebo and increasing doses of melatonin (3 mg, 6 mg, 9 mg, 12 mg, and 15 mg nightly) during alternating 10-day cycles found 9 mg, 12 mg, and 15 mg of melatonin per day decreased scores on the Fibromyalgia Impact Questionnaire, number of tender points, and urinary cortisol levels

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MAD does not require limiting calories, fluids, or protein (56)

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Consequently, early intervention to reinvigorate exhausted T cells by targeting exhaustion mediators can rescue more terminally exhausted T cells