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[DOI] [PubMed] [Google Scholar] 85.Heyworth-Smith D., Hogan P.G

Department of Health and Human Services, ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/

The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

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PMID 15883631

Your skin absorbs the equivalent of 20% concentration
