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This could interfere more intensively with Vit B12 intra-cellular metabolism nullifying the "physiological metabolic rest" of these components (Merola et al

The doe will becomes profoundly depressed or comatose before dying several days later

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(source) Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM
When signaling efficiency declines, the effects often appear gradually