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The FDA's Category 2 restriction specifically governs compounding pharmacies

10.1007/s00438-007-0305-2 62 NarendraS.VenkataramaniS.ShenG.WangJ.PasapulaV.LinY.et al

Drug-Carrier Miscibility in Solid Dispersions of Glibenclamide and a Novel Approach to Enhance Its Solubility Using an Effervescent Agent

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This likely reflects the additive gastrointestinal effects of combining two separate appetite-suppressing compounds
