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doi: 10.3389/fncel.2015.00003

Researchers first isolated it from epithalamin, a substance extracted from the pineal gland

It centers on the structural proteins that hold tissue together, primarily collagen and elastin , and the fibroblasts that synthesize and reorganize the matrix

It is often explored in studies focusing on metabolic pathways, lipid-related processes, and peptide-specific activity

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However, TMRE staining is increased in atfs-1(null) worms when nhr-180 is knocked by RNAi to levels comparable to wildtype worms (Fig