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Riluzole Riluzole, an FDA-approved drug for the treatment of ALS, has been demonstrated to attenuate neural excitotoxicity by blocking glutamate receptors overactivation through prevention of glutamate release from presynaptic terminals by inhibiting voltage-gated Na + and Ca 2+ channels [101, 105, 405], and by elevating GLT-1 expression and activity on striatal astrocytes [406]

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Activation of Multidrug resistance protein 1 In short for this context: The Multidrug resistance protein 1 is a kind of transporter which pups drugs out of the cell