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Figure S27: Distributions of v, k and Gtot in the diabetics above age 40

Advantages No injection required Simple, convenient administration May provide some local benefit to the gastrointestinal tract before degradation Easier for people with needle aversion Disadvantages Substantially lower systemic bioavailability Inconsistent absorption from dose to dose Higher doses needed to achieve similar systemic effects (if achievable at all) Limited evidence for systemic benefits via oral route Potential GI effects from higher doses Emerging Solutions Some manufacturers are exploring encapsulation technologies, enteric coatings, and liposomal delivery systems designed to protect oral peptides from digestive degradation

Tarangelo A, Dixon S

The other ROS-increasing conditions, such as inflammation, dyslipidemia, and upregulation of the renin-angiotensin system (blood pressure regulation by the hormone system) all contribute to increased markers of oxidative stress

doi: 10.1371/journal.pone.0089355 128 ZhouLXueXHouQ

A small sample of your blood will be collected for analysis