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While ongoing research continues to tackle these obstacles, successful clinical translation could ultimately enable earlier diagnosis, better risk stratification, and more effective personalized treatment strategies, offering the potential to significantly reduce the burden of DKD and improve outcomes for patients worldwide

Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes

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DiNicolantonio, J.J., Bhutani, J., McCarty, M.F., and OKeefe, J

Stability and Oligomerization of Mutated SMN Protein Determine Clinical Severity of Spinal Muscular Atrophy