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In the TME, despite various ammonia clearance mechanisms, rapidly proliferating cells, particularly tumor and immune effector cells, have a heightened demand for -KG derived from glutamine breakdown to fuel the TCA cycle, leading to substantial free ammonia production (103)

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Early human trials have explored its effects in mitochondrial-related dysfunction studies

Asthma is a chronic inflammatory disease that can be triggered by allergies, by medication such as aspirin or it can arise within the body through yet unclear molecular mechanisms (78)

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Decreased miR-128-3p in serum exosomes from polycystic ovary syndrome induces ferroptosis in granulosa cells via the p38/JNK/SLC7A11 axis through targeting CSF1