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Small molecule activators of the p53 response
Nat Commun 13:753 Rouach N, Koulakoff A, Abudara V, Willecke K, Giaume C (2008) Astroglial metabolic networks sustain hippocampal synaptic transmission

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PMID 9050888

By integrating findings from diverse disease contexts, this review aims to critically assess the therapeutic potential of targeting AKG-related pathways in brain disorders and to outline key challenges and priorities for future translational research

They disrupt sphingolipid- and cholesterol-rich regions and microdomains in the plasma membrane that initiate inflammatory signaling and reduce the fluidity of the membrane by increasing its saturated FA and cholesterol content [68]
