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Possible etiological factors include increased interleukin production stimulated by toxic uremic milieu, oxidative stress, acidosis, and decreased clearance of inflammatory cytokines by the kidneys [28,29,30]

Depending on experimental settings, cells were stimulated with 100 ng/mL VEGF-C, treated with 25 M CQ, 20 mM ammonium chloride (NH4Cl), and 100 M leupeptin or supplemented with 20 mM AC and cultured for 48 h to analyze sprouting