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Description
In addition to localized glucocorticosteroid delivery, IL-1 receptor antagonist (IL-1Ra), a naturally occurring inhibitor of IL-1 activity, is another potential avenue for intra-articular anti-inflammatory therapeutics

doi:10.1002/cbic.201200210 Randle LE, Goldring CE, Benson CA, Metcalfe PN, Kitteringham NR, Park BK, Williams DP (2008) Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice

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Optional: If the lysate is too viscous, add RNase A (10 g/mL) and DNase I (5 g/mL) and incubate on ice for 10-15 minutes

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