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Similarity and distance metrics To assess transcriptional proximity between tumor and myeloid populations, six metrics were computed: Euclidean, Manhattan, BrayCurtis, and Phi dissimilarities, as well as cosine and Pearson similarities

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Normalised probeset expression measures were calculated using log 2 transformation and quantile normalisation using the Lumi package

At the end of each experiment, hearts treated with diamide (n=6) and diamide + 4-ClDzp (n=6) were snap frozen in liquid nitrogen for determination of myocardial glutathione status as previously described [12]