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1316 These lipid mediators can also play a pivotal role in numerous diseases, including diabetes, 17 obesity, 18 cancer, 19,20 pulmonary, 21 psychiatric, 22 metabolic, 23,24 cardiovascular, 25 and autoimmune diseases

This interaction subsequently promotes partial ubiquitination of NRF2, which enhances its recognition by the ubiquitin-proteasome system

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Differently from GSH, which enters the cells directly, SAG is more stable in blood plasma and, once entered into cell cytoplasm, is converted by cytoplasmatic thioesterases to GSH

(38)revealed bidirectional signaling between gut microorganisms and colonic epithelial cells, suggesting that intact VitD signaling is essential for maintaining a healthy gut microbial community