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Background: Pathogenic mutations in the LRRK2 gene are believed to contribute to PD pathogenesis via elevated LRRK2 kinase activity, thereby making LRRK2 kinase inhibition a promising therapeutic option

The severity depends on how large the dose jump was

Cytochrome P450 enzymes mediate tamoxifen biotransformation, CYP3A4, CYP2B6, CYP2C9, CYP2C19 and CYP2D6 are the essential isoenzymes for this process

Targeting chemotherapeutic drug uptake transporters Two tyrosine kinase inhibitors, nilotinib (an organic anion transporting polypeptide 1B2 (OATP1B2) inhibitor) and dasatinib (an OCTN2 inhibitor), may provide a potential neuroprotective strategy for OIPN, without impacting negatively on their systemic clearances or antitumor efficacies through in vitro and in vivo studies

Recoilless nuclear resonance absorption of gamma radiation: a new principle yields gamma lines of extreme narrowness for measurements of unprecedented accuracy