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This reaction requires vitamin B12 in the methylated form as a cofactor

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Important considerations include understanding that there is significant normal variation in penile size, and the vast majority of men who have concerns actually fall within the normal range (average adult stretched penile length is approximately 13 cm)

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As GSH cannot readily cross the cellular membrane due to its biochemical properties 35 , we assume that GSH excretion is negligible and do not account for it in the equation

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