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Clinically, this manifests as progressive sensory loss (5.07 g monofilament testing) and neuropathic pain (DN4 score 4), correlating with serum 8-OHdG levels ( Hyperglycemia-induced mitochondrial dysfunction in neuronal and Schwann cells leads to excessive O 2 production at complex I and III of the ETC, which initiates a cascade of injury through four primary mechanisms (Wu L

2016;310:G20514

High-performance liquid chromatography (HPLC) and mass spectrometry verification are the accepted purity standards, with 98% or greater purity as the recognized threshold for clinical and preclinical research contexts

The generation of O 2 - is especially enhanced when the electron transfer is reduced with the increased membrane potential [7]

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