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Evidence suggests it may promote weight loss by increasing calorie expenditure

59,60 Specific genes implicated include vascular endothelial growth factor (VEGF), neurotrophic receptor tyrosine kinase 1, sodium voltage-gated channel alpha subunit 2 (SCN2A), angiotensin-converting enzyme, and methylenetetrahydrofolate reductase, with polymorphisms associated with increased DN susceptibility

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224,233 Benfotiamine, a lipid-soluble thiamine derivative, has been shown to activate transketolase activity, thereby redirecting glycolytic intermediates away from the hexosamine pathway