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TPN (especially if it only contains essential amino acids, but not ornithine)

doi: 10.1016/j.ebiom.2017.04.013 72 LinF

Under oxidative stress conditions, healthy mitochondria promptly increase mitophagy level to remove damaged fellows rejuvenating the mitochondrial population and sending fragments of mtDNA as SOS signals to all systems in the human body

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Because the body only produces a limited amount of L-Carnitine on its own, supply can run short, particularly in people who eat little animal protein or have increased metabolic demands