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Since ATF4 is known to work upstream of FGF21 as an early ISR effector, we also studied the metabolic phenotype of BAT-specific dual ATF4/PDSS2 knockout animals (DKO ATF4 ) (Appendix Fig

Actual needs shift with breed, diagnosis, and diet

(2017) suggested that, in principle, the striatal DA deficiency caused by METH may be corrected by DA substitution if safety and patient selection could be resolved

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It is particularly abundant in muscle and brain tissues, where it plays a role in maintaining cellular integrity and performance under stress