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doi: 10.1016/S1875-5364(14)60078-9

other allergic reactions that have been reported include erythema, skin rash (unspecified), pruritus, general malaise, and respiratory difficulty due to bronchospasm

In addition, impaired cholesterol efflux and sustained myelin fragment accumulation within phagocytes produces an inflammatory foamy macrophage phenotype [115] which may lose their ability to effectively phagocytose debris [116]

& Thiele, I

Involved in cellular signaling and regulating calcium levels, CD38 degrades NAD + , using it as a co-substrate for its enzymatic activity 135,136

Statistical analysis with Student's t test on the peak area showed that the general profiles of both glucuronide and glycine conjugated metabolites were enhanced in the DR group, with p values of 0.017 or 0.011, respectively, confirming that the DR group had higher activity in these pathways