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It plays a key role in antioxidant defense, the breakdown of nutrients, and regulation of many biological processes (including immune response & improving insulin sensitivity)

Excitotoxicity in ALS: overstimulation, or overreaction

The ROS-mediated damage is further enhanced in older individuals since during aging, GSH levels appear to diminish in numerous tissues, thereby placing cells at increased risk of stress-related death (Maher, 2005)

Dynamic roles of p53mediated metabolic activities in ROSinduced stress responses

[3] Nevertheless, they are part of the ATP-grasp superfamily, which consists of 21 enzymes that contain an ATP-grasp fold