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Instead, the simultaneous treatment of SFN and erucin at the same 5 M dose, demonstrated similar protective effects, probably in the latter, SFN and erucin significantly enhanced the increase of nuclear protein Nrf2 and GSH levels

Thus, the stage is set for a vicious cycle wherein organelle-driven ferroptosis and immune cell-mediated inflammation mutually reinforce each other, driving COPD progression
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Lu CD, Abdelal AT: The gdhB gene of Pseudomonas aeruginosa encodes an arginine-inducible NAD(+)-dependent glutamate dehydrogenase which is subject to allosteric regulation

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[PubMed 938018][Free Fulltext PMC] 364