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However, there have been several clinical investigations of NAC, including case reports, open-label pilot studies, and double-blind placebo-controlled trials

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MiR-26a reduces inflammatory responses via inhibition of PGE2 production by targeting COX-2

Besides that, A-T is a rare disease (OMIM 208,900) in which incidence ranges from 1: 40,000 to 1: 100,000, and it is caused by a mutation in the ATM gene (ataxia-telangiectasia mutated)

doi: 10.1530/JOE-16-0371 93 RecouvreuxMVFaraoniEYCamillettiMARatnerLAbeledo-MaChadoARulliSBet al

Access this chapter Similar content being viewed by others Abbreviations -KG: -Ketoglutarate 2HG: 2-Hydroxyglutaric acid ASS: Argininosuccinate synthetase ECG: Epicatechin gallate EGCG: Epigallocatechin gallate ETC: Electron transport chain FDG-PET: Fluorodeoxyglucose-positron emission tomography FH: Fumarate hydratase GBM: Glioblastoma multiforme GDH: Glutamate dehydrogenase GLS: Glutaminase GOT: Glutamic-oxaloacetic transaminase GPT: Glutamic-pyruvate transaminase HIF: Hypoxia-inducible factor IDH: Isocitrate dehydrogenase IDO: Indoleamine-2,3-dioxygenase PEG: Poly(ethylene glycol) PHD: Prolyl 4-hydroxylases PLGA: Poly(lactic-co-glycolic acid) PSAT: Phosphoserine aminotransferase RCC: Renal cell carcinomas SDH: Succinate dehydrogenase SHMT: Serine hydroxymethyltransferase TCA: Tricarboxylic acid TDO: Tryptophan-2,3-dioxygenase References Chen, J