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However, posthoc analysis of all of the fibrate trials show significant benefits in terms of reducing CVD events, when looking at the subgroup of patients with elevated triglycerides and low HDL-C and features of the metabolic syndrome or diabetes (670,671)

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doi: 10.1038/oby.2010.147

Targeting the epigenetic dysregulation responsible for BACE1 overexpression may mitigate the pathological drivers of A plaque formation while minimizing associated side effects

52 : 311318 Kulkarni MS, Cox BA and Yielding KL