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Down-regulation of VGF impairs biogenesis of glucagon granules and suppresses glucagon hypersecretion To further elucidate the role of VGF in glucagon hypersecretion, we employed adenovirus-mediated shRNA targeting Vgf (Supplementary Fig

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J Endocrinol Metab, 2013 J Endocrinol Metab, 2014 How to read these results Findings are model-dependent

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state