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Additionally, molecular analysis indicated that up-regulation of -arrestin2, an intracellular protein involved in the desensitization and internalization of dopamine receptors and activation of alternative signaling pathways, may be associated with reduced severity of dyskinesia in levodopa-benserazide-loaded PLGA nanocarrier-treated PD rats

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The antioxidant response element (ARE) is a cis-acting enhancer sequence located in the promoter region of numerous genes involved in detoxification and cytoprotection (122124)