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23 Gprotein activated, phospholipase C (PLC) catalyzes the hydrolysis of phosphatidylinositol 4,5bisphosphate (PIP2) into diacylglycerol (DAG) and inositol1,4,5triphosphate (IP 3 ) that is involved in numerous intracellular signaling pathways associated with various diseases including depression and cancer

To determine whether STR-derived CAR T cells treated with rapamycin had better anti-tumor efficacy in vivo compared to untreated CAR T cells, we inoculated NSG mice with Nalm6 leukemia cells and treated mice with CAR T cells (rapamycin) five days later (Fig

Follow-up testing usually occurs 612 weeks after initial dosing

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