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doi: 10.1016/j.jalz.2017.11.010

Over time, these pathways can become disrupted by stress, aging, and environmental toxins

A vast number of agents targeting neurotrophin receptors with different action mechanisms have been developed and studied in details in vitro and in various animal disorders models recently 10,11,12,13,14

In the context of MDD, whole-body hyperthermia has been reported to elicit a rapid and sustained reduction in depressive symptoms following a single whole-body hyperthermia treatment designed to raise core body temperature to 38.5 C 56,57

REFERENCES: Querol, Luis et al

Phosphorylation of CLIMP63 prevents association with microtubules