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Proc Natl Acad Sci U S A 108, 17755-60 Cortes, J., Barbe, S., Erard, M
J Biol Chem 292(41):1680416809

King, T., Biddle, W., Bhatia, P., Moore, J

Immunologic profile and long-term effect of immunotherapy

Since the EGFR C797S mutant protein confers resistance to the inhibitor osimertinib, PROTAC could be a promising alternative treatment for lung cancer patients harboring this mutation 137

Mitochondrial dysfunction, endoplasmic reticulum stress (ERS), and oxidative stress act as central redox hubs, integrating multiple death pathways through reactive oxygen species (ROS) bursts (O 2 - , H 2 O 2 , OH), calcium dysregulation, and metabolic abnormalities, forming a self-amplifying vicious cycle
