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1 Introduction Major milestones in the immunometabolism field have been recently reached to illustrate how intracellular metabolic circuits are rewired to orchestrate a fine-tuned inflammatory response in activated immune cells

The protein is proteolytically cleaved to monomers that facilitate the aggregation of keratin intermediate microfibrils and collapse of the corneocyte cytoplasm (Steinert et al., 1981), after which the protein is further degraded to amino acids that aid in maintaining moisture in the stratum corneum (Harding and Scott, 1983

33 Metabolomics and statistical analyses These analyses were performed as described 36 and are extensively reported in the Online Supplementary Methods

In case of O 2 , PQQH 2 acts as a catalyst in O 2 -quenching processes and quickly transform -tocopheroxyl radicals into -tocopherol (Ouchi et al., 2013) by mitigating pro-oxidant effects of -tocopheroxyl radicals (Liu et al., 2021)

whereas that of the CA was 85.53 0.49 % (Fig

Storage: Once opened keep refrigerated Store in a cool, dry place away from direct sunlight and heat Additional Instructions: Once opened, refrigerate but do not freeze, use within 90 days