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Shuang et al
In contrast, in mTYR, the Val377 and Ser380 are replaced with proline (P257) and alanine (A260), respectively, therefore it can be considered that there is little VdW clashes of the isopropyl group of -thujaplicin with A260 and P257 (Figure 16)

However, there is mounting evidence that cellular enzymes referred to as NADPH oxidases are an important source of ROS in humans [2]
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