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Published preclinical data in rodents suggests doses equivalent to 200mg+ in humans produce off-target effects on folate metabolism and S-adenosylmethionine (SAMe) pools
For more details, see reference ( The final section will focus on the MM environment, with particular attention to the bone marrow (BM) niche, aiming to identify new players and leverage their unique properties to enhance tumor eradication

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And that was it."
